No abstract

The present investigation describe the synthesis of 8‐(benzyloxy)‐5‐(2‐[1,3‐diphenyl‐1H‐pyrazol‐4‐yl]thiazol‐4‐yl)quinolin‐2(1H)‐one derivatives. Quinolin‐8‐ol was transformed by five step synthetic procedures into 8‐Benzyloxy‐5‐(2‐bromo‐acetyl)‐1H‐quinolin‐2‐one. Subsequently, 8‐Benzyloxy‐5‐(2‐bromo‐acetyl)‐1H‐quinolin‐2‐one condensed with 1,3‐Diphenyl‐1H‐pyrazole‐4‐carbothioic acid amide in the presence of acetonitrile to afford 8‐(benzyloxy)‐5‐(2‐[1,3‐diphenyl‐1H‐pyrazol‐4‐yl]thiazol‐4‐yl)quinolin‐2(1H)‐one derivatives. Synthesized compounds were screened for their antimicrobial activity against gram‐positive and gram‐negative bacteria. Most of the synthesized compounds are found to be active against tested bacterial strains and fungal strain.