Being revered as deities in some religions of the world, non‐human primates (NHPs) often share the same space as humans. Such coexistence and interactions with humans, especially around places of worship, have been known to cause significant changes to the behavior and diet of the NHPs in India. Moreover, the interface may also create an opportunity for zoonotic spillover, similar to the majority of newly emerging or re‐emerging infections that are found to originate from animal sources. These include the SARS COV‐2 virus responsible for the current COVID‐19 pandemic; a catastrophic “One Health” crisis; that has highlighted the interconnections between the health of humans, animals, and the environment. Religious beliefs could potentially influence perceptions, actions, and subsequent One Health outcomes resulting from human–animal interaction, which could impact human and animal welfare. Greater insight in this area could provide a better understanding of the complex relationships between humans and NHPs; that may play an important role in mitigating conflict as well as the spillover of zoonotic disease at the human–NHP interface.