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This paper presents a comparison between some well-known control schemes such as feedback, feedback plus feed-forward, cascade and cascade plus feed-forward for controlling a third-order process. The controller applied in various control schemes is a PID controller that has been tuned using Ziegler Nichols (ZN) and relay auto-tuning (RA) methods. The comparative analysis is based upon various performance measures such as rise time (t r), settling time (t s), maximum overshoot (M p), steady-state error (e ss), integral of absolute error (IAE), integral of square error (ISE), integral of time square error (ITSE), and integral of time absolute error (ITAE). Simulation results show that the RA method provides superior performance in case of feedback plus feed-forward and cascade control schemes. On the other hand, the ZN method proves to be better in case of cascade plus feed-forward control scheme.

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Dietary polyphenols are protective for chronic diseases. Their blood transport has not been well investigated. This work examines multiple classes of polyphenols and their interactions with albumin, lipoproteins, and red blood cell (RBC) compartments using four models and determines the % polyphenol in each compartment studied. The RBC alone model showed a dose–response polyphenol association with RBCs. A blood model with flavanones determined the % polyphenol that was inside RBCs and bound to the surface using a new albumin washing procedure. It was shown that RBCs can methylate flavanones. The whole blood model separated the polyphenol into four compartments with the aid of affinity chromatography. More polyphenols were found with albumin and lipoproteins (high-density lipoproteins and low-density lipoproteins) than with RBCs. In the plasma model, the polyphenols associated almost equally between lipoproteins and albumin. RBCs and lipoproteins are shown to be important reservoirs and transporters of polyphenols in blood.