X-rays were discovered in 1895 and since then much has been written about Wilhelm Roentgen and the events surrounding the discovery. However, there have been only scattered references in the literature about the early workers who dedicated their life, and death, to X-rays. Radiology has come of age since then. Large exposure times have been reduced to milliseconds and there has been a change from analogue to digital. The advent of new and rapidly developing modalities and the ubiquitous presence of cone beam CT (CBCT) highlight the need to remember the early victims of X-rays, especially with the lack of universal guidelines for taking a CBCT scan. The aim of this article is to alert the oral radiologist to exposing patients irrespective of need, and to pay respect to the victims on the 116th anniversary of the discovery of X-rays.
EMIT Liver cirrhosis a b s t r a c tBackground: Chronic liver diseases (CLD) are quite prevalent throughout the globe. Its early and correct diagnosis is always a concern among physicians, especially the residual liver function. For this various substrates like caffeine are being investigated in body fluids like serum and saliva. Saliva as a study sample has its own advantages due to its non invasiveness; it can be very useful study sample.Methods: 30 Subjects with CLD and 15 healthy controls were administered 200 mg of caffeine. Subjects classified into severity groups (class-A-mild-n ¼ 9, B-moderate-n ¼ 11, and C-severe-n ¼ 10) based on "Child-pugh classification" of severity of liver disease. After 17 h of dietary caffeine restriction and before drug administration, 0 h salivary sample was taken. After the dose of caffeine, 4 and 16 h saliva sample was taken. Blood sample was taken from controls only at same time points. These samples were analyzed on semi automated analyzer using Enzyme Multiplied Immunoassay Technique (EMIT) by spectrophotometric method. Caffeine clearance values were calculated and results were statistically analyzed.Results: Significant correlation was found between serum caffeine clearance and salivary caffeine clearance (SCC). Controls showed higher mean of SCC value of 1.6 ± 0.2 ml/min/kg while SCC values of subjects were less, with mean of 0.5 ± 0.2 ml/min/kg. Significant correlation was found between degree of hepatic dysfunction and SCC values.Conclusion: Saliva can be used for diagnosis of CLD and assessment of residual liver function in CLD as alternative to serum.
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