The aim of this review is to estimate contribution of orthostatic circulatory changes to the development of vascular disorders. In the XXI century, the cardiovascular disorders remain a most widespread pathology responsible for the high mortality and disablement rate throughout the world. Their main risk factors have been identified, but the influence of gravity on the cardiovascular system is usually disregarded even though it exerts an appreciable effect of special importance for neurohormonal regulation. Disturbed regulation of orthostatic changes in circulation manifest as orthostatic arterial hypertension is a well known risk factor of cardiovascular pathology. The review is focused on orthostatic circulatory disorders and cause-and-effect relationships between certain risk factors in pathogenesis of these conditions.