PurposeInformation Systems (IS) research has built up a considerable understanding of digital platform ecosystems, while policymakers worldwide are aiming to introduce platform regulations that seek to erode fundamental mechanisms of digital platforms. This viewpoint article provides an introduction to how platform regulation affects our current understanding of digital platform ecosystems and suggests opportunities for future research.Design/methodology/approachA detailed analysis of the effects of the European Union (EU) Digital Markets Act (DMA) on current findings of organizational, technical and economic IS platform research.FindingsGovernment regulations of digital platforms such as the DMA likely affect the central mode of operation of platforms in the scope of the regulation. The authors preconceive a major impact on platform openness, governance, steering the platform supply-side, modularity, nestedness, network effects, pricing and single-/multi-homing. In addition, the authors present opportunities for future research in each of these IS platform research streams.Originality/valueLandmark regulations implemented in the past, such as the General Data Protection Regulation (GDPR), caused paradigm changes that fertilized research opportunities in IS and beyond. This viewpoint article aims to nudge studies that examine the changed mode of operation of platforms following platform regulation.