Copper-amyloid-β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid-β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid-β peptides.
Kupferionen (rote Kugel im Bild) akkumulieren in Amyloid‐β‐Plaques und spielen dort eine Rolle bei der Erzeugung reaktiver Sauerstoffspezies (ROS). Massenspektrometrische Studien zeigen, an welchen Stellen eine oxidative Schädigung auftritt, was neue Einblicke in den Mechanismus der ROS‐Produktion bietet und dadurch zum besseren Verständnis der Pathogenität von Amyloid‐β‐Peptiden beiträgt.
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