A simple, efficient and environmentally friendly one-pot synthesis of b-hydroxy sulfoxides in water under microwave irradiation is reported.

Chloroperoxidase can be microencapsulated in silica gel grown around the enzyme by sol-gel techniques. These materials can be usefully employed as catalysts for the asymmetric sulfoxidation of alky aryl sulfides with hydrogen peroxide, with high yields and ee's > 99%. The catalyst an be recycled up to three times without loss of activity and enantioselectivity

Enantioselectivities up to 75 % have been found in the catalytic mono-oxidation of di-tert-butyl disulfide and related compounds as well as of ketene-S,S-acetals with an in situ generated chiral dioxirane. The effect of solvents on the enantiomeric excess has also been examined.

Der Käfig hilft: Mit Sol‐Gel‐Methoden wurde Chlorperoxidase (CPO) in mikroporöses Kieselgel eingeschlossen. Diese eingeschlossene CPO katalysiert die enantioselektive Oxidation organischer Sulfide (siehe Schema) und kann ohne merklichen Verlust an Aktivität und Enantioselektivität rezykliert werden.

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