Skin aging is a complex biological process. Skin aspect is considered as a sign of well‐being and of beauty. In view of this, noninvasive and/or minimally invasive anti‐aging strategies were developed. Adenosine, a well‐known nucleoside, may play a role in skin rejuvenation. Adenosine receptors belong to the G protein‐coupled receptors superfamily and are divided into four subtypes: A1, A2A, A2B, and A3. The adenosine receptors expressed by skin are mainly the A1 and A2A subtypes. In the hypodermis, adenosine through the A1 receptor stimulates lipogenesis and adipogenesis. In the dermis, adenosine through the A2A receptor subtype stimulates collagen production. Moreover, the nucleoside increases new DNA synthesis and subsequently protein synthesis in dermal cells. Activation of adenosine receptors by interacting with various skin layers may induce a decrease in the amount of wrinkles, roughness, dryness, and laxity. This article has reviewed the mechanisms through which adenosine modulates biological mechanisms in the skin tissues and the effect of preparations containing adenosine or its derivatives on the skin.

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