The new diorganotin (IV) complexes of composition [Me2SnCl(3,5‐(NO2)2C6H2(OH)CONHO)] (I) and [n‐Bu2SnCl(3,5‐(NO2)2C6H2(OH)CONHO)] (II) have been synthesized by the reactions of Me2SnCl2 and n‐Bu2SnCl2 with potassium 3,5‐dinitrosalicylhydroxamate [3,5‐(NO2)2C6H2(OH)CONHOK]‐ a ligand of biological significance bearing –NO2 and –OH substituents presumed to yield complexes with efficient bioactivity. The complexes have been characterized by elemental analyses, IR, 1H, 13C and 119Sn NMR and mass spectrometry in order to study the ligational behavior and probale geometry around tin as the ligand might show different bonding modes and geometry in complexes. The geometries of (I) and (II) have been computed using B3LYP/6–31 + G(d,p) set by DFT method and the vibrational frequencies, 1H and 13C NMR spectra compared with the experimental data. A comparison of computed bond lengths (C=O, C‐N, and N‐O) of (I) and (II) with that of free ligand, the Sn‐O bond lengths, bond angles coupled with 119Sn NMR and IR spectral data have suggested coordination through carbonyl and hydroxamic oxygens (O, O coordination) displaying five‐coordinate distorted trigonal‐bipyramidal geometry around tin. The thermal behavior of (I) and (II) has been studied by thermogravimetric techniques (TGA, DTG, DTA) and various kinetic parameters have been calculated. The electrochemical behavior of ligand, (I) and (II) studied by cyclic voltammetric technique has shown ligand centered redection. The HOMO‐LUMO energies and orbitals, global reactivity descriptors, various thermodynamic parameters and dipole moment (μ) have been computed to determin the molecular properties of complexes. The in vitro antimicrobial activity assay against bacteria and fungi by MIC method has indicated higher potency of (I) than (II). The in vitro cytotoxicity on human muscle rhabdomyosarcoma (RD) by MTT method and the antioxidant potential by DPPH free radical scavenging showed higher inhibitory effect of complexes than ligand.

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The new diorganotin(IV) complexes of composition [Me2Sn(C6H5OCH2CONHO)2](I) and [n-Bu2Sn(C6H5OCH2CONHO)2](II) have been synthesized by the reactions of Me2SnCl2andn-Bu2SnCl2with potassium phenoxyacetohydroxamate (PhOAHK=C6H5OCH2CONHOK) in 1:2 molar ratio in methanol and benzene solvent medium and characterized by elemental analyses and spectroscopic techniques (infrared,1H nuclear magnetic resonance and mass spectrometry). The [O,O coordination] through carbonyl and hydroxamic oxygen atoms and distorted octahedral geometry around the mononuclear tin has been inferred. The electrochemical behavior of complexes studied by the cyclic voltammetric technique has shown quasi-irreversible two-step reduction from tin (IV) to tin (II). Thermal behavior of complexes studied by the thermogravimetric technique in N2atmosphere has yielded SnO as the decomposition product. Thein vitroantimicrobial activity assays against various pathogenic Gram-negative bacteria, namely,Salmonella typhi,Escherichia coli; Gram-positiveBacillus cereusandStaphylococcus aureusand fungiAspergillus nigerandAlternaria alternataby the minimum inhibitory concentration method have shown their potential as promising antimicrobial agents compared to the respective standard chloramphenicol and nystatin drugs.

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