Cadmium (Cd) is one of the most toxic heavy metal. Numerous tissues both in vitro and in vivo suggest that Cd induced lipid peroxidation. The presence of antioxidant can inhibit this process. This present study was designed to determine the effects of mango, papaya, and banana juices on malondialdehyde levels (MDA) during Cd exposure in vitro. The result of this study showed that there were a significant difference MDA level between three selected fruits juices. The result of this study also showed the significant differences MDA level between the concentration of each fruit juices. The highest correlation was found between banana juices and MDA levels with IC50 1.12 and followed by papaya and mango juices with IC50 1.37 and 3.87 respectively. The findings of this study suggest that the three selected fruits juices may exert its protective action against Cd-induced lipid peroxidation in liver homogenate in vitro possibly through its antioxidant mechanism.