Present study is aimed at the development of oro-dispersible tablets of clonazepam using natural superdisintegrants. Mucilage of Hibiscus rosa sinensis leaf and seeds of Ocimum basilicum were extracted, evaluated for the organoleptic, physicochemical parameters. The dried mucilage was used as superdisintegrant for the preparation of orodispersible tablets by direct compression method. The blends were evaluated for the pre-compression parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time, drug content and dissolution studies. The drug release profiles of the two superdisintegrants were compared. The optimized formula F10 was subjected to wet granulation using PVP in IPA as the dry binder. The tablets containing 5%w/w dried mucilage of Ocimum basilicum as superdisintegrant prepared by direct compression technique was found to be the best which disintegrated in 22 sec. with 99.8%drug release. The tablets were found to be stable during the accelerated stability studies conducted for three months at 40±2 0 C/75±5% RH.