Nationale (GIGN) is a police special force unit from the military. Its main missions are counter-terrorism, fight organized crime, and also protection and security of vital keypoints of the nation and state, in France and overseas as well. The GIGN is trained to work under chemical, biological, radiological, or nuclear (CBRN) conditions. The aim of this study is to improve CBRN medical support. Methods: An in-depth literature analysis was conducted to the great expertise of the GIGN medical unit and of the French Service de Sante des Armees. Results: Before a mission, the physicians of the military are key actors to train soldiers to face CBRN conditions. They define medical countermeasures including personal protective equipment (PPE) and antidote kits including Ineurope® auto-injecting syringes that contain atropine, pralidoxim, and diazepam. During the mission, the medical units, including the GIGN, are able to move and work in contaminated areas. They can initiate the medical care of classic soldier wounds and CBRN contaminated wounds as well. The impact of the pharmaceutical and antidote kits and specific training are of great importance to accomplish the medical mission while wearing PPE. They can also strengthen CBRN decontamination modules of the Gendarmerie. Conclusions: The CBRN risk must be considered for Special Force medical unit: training, constantly adapting the protective equipment and specific therapeutics to the risk is a major challenge.