Effectiveness of restoration/repopulation measures may be strongly hindered by the ability of the target species to cope with the environmental conditions of the receiving area. Although a species has been reported previously for a given area, the environmental conditions and human pressures may have changed, potentially making any restoration attempt ineffective. Evidence is provided showing that the endangered ferruginous limpet Patella ferruginea can complete its reproductive cycle in the northernmost sector of the western Mediterranean. This supports the idea that the reintroduction and the strict protection of P. ferruginea in the extreme north of its historical geographic range could be effective for the recovery of the species in this area and ultimately the establishment of reproductively viable and stable populations. Verification of gonadal maturation of specimens experimentally established on the Gulf of Genoa (Ligurian Sea) coastline, as well as evidence of sex change in one individual (the first outside the Alboran Sea), provides further support of the potential for individuals to complete their reproductive cycle in this area. The results support the potential of actions for the restoration of viable populations of the species along the Ligurian coasts through the introduction of juveniles obtained exclusively by aquaculture techniques, in order to mitigate any impact on donor sites.