Background and objectives: Hydrazone ligands along with their metal complexes exhibit important biological potential. Our objective was to synthesize new Schiff base ligands and their metal complexes which can act as vital drugs. Metal complexes of Zn(II), Ni(II), Cu(II), Mn(II), Co(II), Hg(II), Cd(II), Sn(II), Zr(II), and Fe(II) were synthesized from a novel Schiff base (1-((3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)methylene) hydrazine) ligand. The synthesized metal complexes were studied for antimicrobial, antimalarial, and anti-tubercular activity.Methods: Schiff base hydrazone (1-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) methylene) hydrazine) ligand and metal complexes were synthesized using the condensation method. The ligand and metal complexes were characterized using analytical techniques. Results:The synthesized ligand was found to be bidentate in nature. The stoichiometry of the metal ions to ligand was 1:2. Complexes of Co(II), Cu(II), Mn(II), and Cd(II) displayed excellent antimicrobial activity. The Mn(II) complex was active against M. Tuberculosis, while Cu(II) and Cd(II) exhibited excellent activity against malaria compared to standard drugs. The present work reports synthesis, characterization, and biological screening for antitubercular, antimicrobial, and antimalarial activity of metal complexes of bidentate (1-((3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)methylene) hydrazine) Schiff base ligands. Among the synthesized series of metal complexes, Cu(II) and Cd(II) complexes displayed excellent activity against malaria and moderate to good antimicrobial and anti-tubercular activity was observed for the synthesized metal complexes. Conclusions:We report the synthesis of a new (1-((3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)methylene) hydrazine) Schiff base bidentate ligand and metal complexes. Metal complexes exhibit biological activities.