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Depression is a mental disorder with an estimated 121 million people affected. The WHO has identified the depressive disorder as a prevalent mental health disorder and the fourth leading cause of impaired activities and premature death in the world. It is conjoined with momentous morbidity and mortality, and psychosocial and occupational impairment. 1 During the last few years, there has been a considerable advancement in the drug treatment for depression. However, the efficacy of currently available drugs for treating depression often lack in consistency and many of them may result in side effects. 2 This emphasises the need for more research to identify newer drugs in the treatment of major depression and to understand their mechanisms. A number of herbal medicines or their active principles have been evaluated for psychiatric conditions with promising benefits, such as Piper methysticum, Ginkgo

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