Introduction. The article is devoted to the calibration and graduation of the multi-sensor gas analyzer developed at the V.M. Glushkov Institute of Cybernetics of National Academy of Sciences of Ukraine. The modern trend in the development of medical equipment, in particular, containing built-in measuring devices, consists in its miniaturization, intellectualization, the use of information technologies, and the introduction of wireless and network means of data transmission. The purpose of the article is to design, create electronics and software for recording the concentration of three gases (oxygen, carbon dioxide and carbon monoxide), test and calibrate the device. Results. Three prototypes of sensor modules for oxygen, carbon dioxide and carbon monoxide have been created. The structure, scheme of connection of sensor modules, and the principle of operation of the gas analyzer was described. Testing and optimization of these prototypes were performed. Auxiliary pneumatic equipment for checking the performance of devices, their calibration and graduation was manufactured. Measurement technique was developed and test measurements of the specified gases were performed. The calibration technique was developed and the device was calibrated using two test gas samples such as ethanol vapor and air-gas mixture of carbon dioxide. In addition, a special software has been developed, which allow observe a registered input signal from sensor modules and store it to the file. Conclusions. As a result of the work, prototype of the device was created, its testing, calibration and graduation were carried out at the State Enterprise "Ukrmetrteststandart", 4 certificates of metrological attestation were obtained. The gas analyzer can be used for screening of healthy persons based on study of exhalation to predict the risk of diseases. Keywords: multi-sensor gas analyzer, oxygen, carbon dioxide, carbon monoxide, calibration, graduation.

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Інститут кібернетики імені В.М. Глушкова Національної академії наук України Будник М.М. Інститут кібернетики імені В.М. Глушкова Національної академії наук України Ходаковський М.І. Інститут кібернетики імені В.М. Глушкова Національної академії наук України Будник В.М. Інститут кібернетики імені В.М. Глушкова Національної академії наук України Риженко Т.М. Інститут кібернетики імені В.М. Глушкова Національної академії наук України Мудренко М.І. Інститут кібернетики імені В.М. Глушкова Національної академії наук України Чайковський І.А.