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Background: Basal cell carcinoma (BCC) is the most frequent skin neoplasm in Brazil, with increased incidence in the last decades. There are few studies from the Southern Region of Santa Catarina on the epidemiological profile of this tumor. Objectives: To establish epidemiological data on BCC in the Association of Municipalities of the Region of Laguna / SC (AMUREL). Methodology: An observational study with a cross-sectional analysis with positive anatomicopathological reports for BCC between 2009 and 2017 was carried out in a laboratory in Tubarão (SC). The variables collected were year of diagnosis, age, gender, city of origin, location of the lesion, histological subtype, lesion diameter and marginal compromise. Results: A total of 4,125 reports were identified, with a diagnosis of BCC in the AMUREL region with a predominance in men, with a higher frequency in the age group ranging from 61 to 80 years of age and located mainly in the encephalic and cervical regions, being the nodular subtype the most prevalent. A BCC incidence coefficient was found of 93.95 in 2009 and 161.86/100,000 inhabitants in 2017, resulting in an increase of 72%. Limitations of the study:The study was collected in only one laboratory in the stipulated region. Conclusions: A total of 4,125 people were diagnosed with BCC in the AMUREL region, with an incidence increase of 72% in 2009, when compared to 2017. In both genders, the sclerodermiform subtype had the highest frequency in relation to the marginal impairment. There was a prevalence of margins impaired after resection in 29% of the lesions, and a diameter ≤ 2 cm was the most found.