BackgroundVaccine hesitancy presents an obstacle to the campaign to control COVID-19. It has previously been found to be associated with youth, female gender, low income, low education, low medical trust, minority ethnic group membership, low perceived risk from COVID-19, use of certain social media platforms, and conspiracy beliefs. However, it is unclear which of these predictors might explain variance associated with others. MethodsAn online survey was conducted with a representative sample of 4343 UK residents, aged 18 to 75, between 21 Nov and 21 Dec 2020. Predictors of vaccine hesitancy were assessed using linear rank-order models. ResultsCoronavirus vaccine hesitancy is associated with youth, female gender, low income, low education, high informational reliance on social media, low informational reliance on print and broadcast media, membership of other than white ethnic groups, low perceived risk from COVID-19, and low trust in scientists and medics, as well as (to a much lesser extent) low trust in government. Coronavirus conspiracy suspicions and general vaccine attitudes appear uniquely predictive, jointly explaining 35% of variance. Following controls for these variables, effects associated with trust, ethnicity, and social media reliance largely or completely disappear, while the effect associated with education is reversed. ConclusionsStrengthening positive attitudes to vaccination and reducing conspiracy suspicions with regard to the coronavirus may have a positive effect on vaccine uptake, especially among ethnic groups with heightened vaccine hesitancy. However, vaccine hesitancy associated with age and gender does not appear to be explained by other predictor variables tested here. This is an Accepted Manuscript for Psychological Medicine as part of the Cambridge Coronavirus Collection. Subject to change during the editing and production process.

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Objectives To investigate factors associated with anger or confronting others due to COVID-19. Design Online cross-sectional survey. Setting Data were collected between 17 and 20 July 2020. Participants A total of 2237 participants living in the UK aged 16–75 years. Main outcome measures Reporting having had arguments, felt angry or fallen out with others because of COVID-19. Reporting having confronted or reported someone to the authorities, or that you had been confronted or reported to the authorities, for not wearing a face covering; not keeping your distance from others or being in too large a group; or alternatively following recommended measures too carefully. We used logistic regression analyses to identify factors associated with anger and confrontation. Results Most participants reported having had arguments, feeling angry or fallen out with others because of COVID-19 (56%, n = 1255). Twenty-two percent (n = 500) of participants reported that they had confronted or reported someone. Fourteen percent (n = 304) of participants reported that they had been confronted or reported by someone. Confronting someone, having been confronted and feeling angry or having had arguments were strongly associated with each other. Anger and confrontation were associated with younger age, greater likelihood of experiencing significant financial difficulties due to the pandemic, greater perceived risk of COVID-19 and getting information about COVID-19 from social media. Conclusions Measures put in place to prevent the spread of COVID-19 have caused considerable strain. Increased support, clear messaging on the rationale for easing restrictions and combatting misinformation on social media may all help decrease tension.

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ObjectiveTo test whether demographic variation in vaccine hesitancy can be explained by trust and healthcare experiences.DesignCross-sectional study.SettingData collected online in April 2021.ParticipantsData were collected from 4885 UK resident adults, of whom 3223 had received the invitation to be vaccinated against the novel coronavirus and could therefore be included in the study. 1629 included participants identified as female and 1594 as male. 234 identified as belonging to other than white ethnic groups, while 2967 identified as belonging to white ethnic groups.Primary and secondary outcome measuresUptake of coronavirus vaccination.ResultsMembership of an other than white ethnic group (adjusted OR (AOR)=0.53, 95% CI 0.35 to 0.84, p=0.005) and age (AOR=1.61, 95% CI 1.39 to 1.87, p<0.001 for a 1 SD change from the mean) were the only statistically significant demographic predictors of vaccine uptake. After controls for National Health Service (NHS) healthcare experiences and trust in government, scientists and medical professionals, the effect associated with membership of an other than white ethnic group appears more marginal (AOR=0.61, 95% CI 0.38 to 1.01, p=0.046), while the effect associated with age remains virtually unchanged. Exploratory analysis suggests that NHS healthcare experiences mediate 24% (95% CI 8% to 100%, p=0.024) of the association between ethnicity and uptake, while trust mediates 94% (95% CI 56% to 100%, p=0.001) of the association between NHS healthcare experiences and uptake.ConclusionsMembers of other than white ethnic groups report inferior NHS healthcare experiences, potentially explaining their lower reported trust in government, scientists and medical professionals. However, this does not fully explain the ethnic gap in coronavirus vaccination uptake.