One of the most common and reliable methods of water treatment is the method of thermal distillation. Despite the reliability of the method, its application is constrained by high energy intensity. The most effective way to reduce the cost of production of distillate is the use of thermal transformers, providing regenerate and heat recovery phase transformations of the distillate. The use of working fluid with the most favorable thermodynamic properties is of paramount importance for the creation of high efficiency thermotransformers. The work is considered working fluid for high-temperature heat pumps and the results of the calculation-experimental study of high-temperature vapor compression heat-pumping distiller on natural working substance n-pentan.