Lipomas in the oral cavity are rare benign soft tissue mesenchymal neoplasms, representing1% of all benign oral tumors. Very few cases of tonsillar lipoma have been reported in the English literature. The diagnosis and differentiation of lipoma with clinically similar lesions, such as squamous papilloma, adenomas, chondromas, hamartomas and teratomas, is essential for correct treatment management and follow-up. We describe a rare case of palatine tonsil lipoma in a 67-year-old female and an updated review of the sparse English literature. How to cite this article Abu-Ghanem S, Zilker V, Trejo L, Fliss DM. Classic Lipoma of the Palatine Tonsil: Case Report and Review of the Literature. Int J Head and Neck Surg 2013;4(1):41-43.