Collagen is the most abundant protein in vertebrates, which constitutes about 30% of the total proteins and has been widely used in food, cosmetic, biomedical, and pharmaceutical industries. The conventional source of collagen is from bovine and pig. However, the outbreak of prion diseases, such as bovine spongiform encephalopathy, has with prion diseases. In addition, their skin, bones, scales, are rich in collagen type I. A simple method has been used 0 C ed using animal model of obesity. For this purpose, the rats were fed with a high-calorie diet, which consisted of a for four weeks. After that the animals were orally administrated with marine collagen fragments extracted from the Found changes could be result of decrease of food intake and increase of water intake in compare with the rats in HCD group.