Carboxyl-terminated poly(acrylonitrile-co-butadiene) (CTBN)-grafted epoxidized linseed oil (ELO) (CTBN-g-ELO) was synthesized and used as an effective toughener to simultaneously enhance the mechanical properties and fracture toughness of epoxy resin (EP). The ELO was fabricated from linseed oil via epoxidation processing. The characteristics of the ELO and CTBN-g-ELO, such as the average molecular weight and chemical structure, were determined using gel permeation chromatography, proton nuclear magnetic resonance, and Fourier transform infrared spectroscopy. The effects of the CTBN-g-ELO loading on the characteristics of the EP were investigated in detail. The test results indicated that by adding 15 phr CTBN-g-ELO, the tensile strength, impact strength, and critical stress intensity factor (K IC ) were significantly increased, by approximately 23.62, 91.8, and 33.8%, respectively, compared with pristine EP. The glass-transition temperature (T g ) and storage modulus, which were examined via dynamic mechanical thermal analysis and differential scanning calorimetry, respectively, exhibited decreasing trends. Scanning electron microscopy revealed that the CTBN-g-ELO existed as spherical particles in the EP, helping to stop the crack growth and change the crack growth directions.

Series of novel triterpenoid hybrids were designed and synthesized by introducing 2-aminobenzamide moiety at C28 position of triterpenoid derivatives. Thirteen new conjugates were thus successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity in KB and HepG2 cancer cell lines.

A series of new hydroxamate derivatives of lupane triterpenoids has been designed and successfully synthesized. The synthesized compounds were evaluated for their in vitro antitumor activity using the 3-[4,5-dimethylthiazol-2-yl]−2,5-diphenyltetrazolium bromide-based assay against the human cancer cell lines KB and HepG2. Most of these derivatives possess at least moderate cytotoxic activity and the hydroxamate derivative compounds 3c, 3e, 7a, and 15b could be lead compounds for further optimization to develop novel anticancer agents.

Twelve new compounds including 2-aminobenzamide derivatives bearing benzothiazole and phenylamine moiety were designed and synthesized. The synthesized compounds were tested their cytotoxic activity against A549 and SW480 tumor cell lines. Compounds 3a and 3c exhibited cytotoxicity toward A549 cell line with IC50 values of 24.59 and 29.59 µM, respectively.

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