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METHODSThe rats used were adult albinos (150-250 g.) of the Wistar strain, and the mice were adult albino females (2C25 g.) of the Strong A strain. Tritiated thymidine (3HT), specific activity 5c per mM, was obtained from the Radiochemical Centre, Amersham. 3H labelling of white cells was achieved by means of a course of 3 injections, each of 0.5 pc per g., as previously described (Spector et al.). To secure adequate labelling of small lymphocytes, a course of 28 daily intraperitoneal injections, each of 0.5 pc per g., was given to the mice. Colloidal carbon was injected intravenously as before (Spector et al.).Granulomatous inflammation was produced by injecting Complete Freund's adjuvant subcutaneously and intradermally into the dorsum of the feet. The adjuvant was emulsified before use with an equal volume of sterile isotonic saline in an ultra-turrax homogeniser; the quantity of emulsion injected was 0.05 ml. per Present address:

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