In more than ten thousand transfusions given over a four-year period to 1,649 patients, the inadence of urticaria1 reactions wapl 1.1 per cent. There were no hemolytic tramfusion reactions and none due to bacterial contamination or to bacterial ppgem. There were 276 "Febrile Nonhemolytic" reactions for an incidence of 2.5 per cent.T h e clinical picture described for reactiona due to leukocyte incompatibility waa extremely rare. Eighteen per cent of patients raponding with fever to tramfusion did M I following their very first transfusion. Many patients had only one tramfuion reaction dapite many further transfusions and others had many successive reaction4 followed by numerous reaction-free transfusions of blood from which leukocytes had not been removed. examination of the sources and the quantitative methods of testing pyrogen. Quart. J. Pharm. and Pharmacol. 21: 240, 1948. p. 55.
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