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A single dose of polychlorinated biphenyls caused an increase of 8-aminolevulinic acid synthetase activity and porphyrin content in rat liver. 8-aminolevulinic acid dehydratase activity was not altered significantly. A maximum effect was obtained 24 hrs after treatment, and the rate limiting enzyme of porphyrin synthesis returned to a normal level of activity at the third day after treatment. On the contrary the porphyrin content of the liver remained elevated up to 4 weeks after a single injection of polychlorinated biphenyls. After administration of polychlorinated biphenyls the kinetic properties of S-aminolwulinic acid synthetase of rat liver were found to be altered : an increase of Vm,, was accompanied by a decrease of K, . The threshold dose for an increase of 8-aminolevulinic acid synthetase activity and porphyrin content of rat liver after a single dose of polychlorinated biphenyls was about 0.019 mmoVkg body weight for starved animals. At this dose range n o significant differences in response of the parameters examined were seen when polychlorinated biphenyls with variable chlorine contents were administrated. A maximum effect for S-aminolevulinic acid synthetase was obtained by a threefold dose, and no further increase was obtained by much higher doses, whereas increasing response up to these high doses was seen for the porphyrin content of the liver. At high doses the activity of 8-aminolevulinic acid synthetase increased with increasing chlorine content of the polychlorinated biphenyls.

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Grote: Verhütung von Skelettfehlbildungen nach mütterlichem Blutverlust durch Elektrolytersatz Verhütung von Skelettfehlbildungen nach mütterlichem Blutverlust durch ElektrolytersatzUntersuchungen an Kaninchen haben gezeigt, daß die embryonale Entwicklung des Rumpfskelettes zur Zeit der Somitenbildung durch einen mütterlichen Blutverlust fehlgeleitet werden kann (3, 4). Die Erscheinungsform der beobachteten Mißbildungen entspricht Fehibildungen bei Hühnerembryonen nach einem Blutverlust durch Punktion der Aorta oder durch Einschneiden eines Zweiges der V. omphalomesenterica (2).Fehlerhafte Somitenbildungen können genetisch bedingt sein (1, 6) oder durch verschiedene exogene Faktoren ausgelöst werden und führen zu einem voñ Theiler (7) als »Wirbel-Rippen-Syndrom« bezeichneten Symptomkomplex mit typischen Wirbelmißbildungen und Rippenverschmelzungen (Abbildung 1* und 2).

The detection rate for female carriers of haemophilia A was investigated by comparing the one-step method of Hardisty and Macpherson for biological activity of factor VIII with quantitative immunoelectrophoresis (after Laurell) for factor VIII-associated antigen. Certain or probable positive results were obtained in 25 of 27 female carriers by the quantitative immunoelectrophoresis, but only in 18 when measuring factor VIII activity.