Ultrafast-optical-pump -structural-probe measurements, including ultrafast electron and xray scattering, provide direct experimental access to the fundamental timescales of atomic motion, and are thus foundational techniques for studying matter out of equilibrium. High-performance detectors are needed in scattering experiments to obtain maximum scientific value from every probe particle. We present the first ultrafast electron diffraction experiments to deploy a hybrid pixel array direct electron detector, and we show that its single-particle sensitivity, high dynamic range and 1 kHz frame rate enable new probe modalities in electron-based structural dynamics.Specifically, we perform measurements on a WSe 2 /MoSe 2 2D heterobilayer that resolve the weak features of diffuse scattering and moiré superlattice structure without saturating the zero order peak. Enabled by the detector's high frame rate, we show that a lock-in technique provides diffraction difference images with signal-to-noise at the shot noise limit. Finally, we demonstrate that a fast detector frame rate coupled with a high repetition rate probe can provide continuous time resolution from femtoseconds to seconds, enabling us to perform a scanning ultrafast electron diffraction experiment that maps thermal transport in WSe 2 /MoSe 2 and resolves distinct diffusion mechanisms in space and time.

We report the design and performance of a time-resolved electron diffraction apparatus capable of producing intense bunches with < 200 fs rms duration, single digit micron probe sizes, and simultaneously long coherence length. To generate high brightness electron bunches, the system employs high efficiency, low emittance semiconductor photocathodes driven with a wavelength near the photoemission threshold at a repetition rate up to 250 kHz. We characterize spatial, temporal, and reciprocal space resolution of the apparatus and perform proof-of-principle measurements of ultrafast heating in single crystal Au samples.