The in vitro activities of N-fonnimidoyl thienamycin (MK0787) and nine other antibiotics were tested against 129 Colonies of isolates to be tested were picked from nutrient agar slants, suspended in 1 ml of MuellerHinton broth, and incubated overnight at 370C. Fifty microliters of a 1:1,000 dilution of this culture in Mueller-Hinton broth was added to each well of the microtiter plate, resulting in final inocula (determined by representative colony counts) of from 4.5 x 104 to 1.0 x 1O colony-forming units per ml. The concentrations of antimicrobial agents in these wells ranged from 0.12 to 100 ug/ml. The MIC was defined as the lowest

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