IntroductionDepression is commonbut still ignored in general practice whereas it is a source of handicap, psychiatric and somatic morbidity.AimsTo assess the punctual prevalence of major depression in primary healthcare centers in Tunisia.MethodsA Transversal study during march 2007 was conducted in three primary healthcare centers in Hammamet city. All partients having sixteen years or older were evaluated by the Cluster A of the Mini International Neuropsychiatric Interview (MINI). Patients meeting criteria for major depressive disorder had subsequently been assessed by the MADRS depression scale. A score greater or equal to 20 was considered as the threshold score for the diagnosis of major depressive episode.Results199 patients participated at the study (participation rate = 70%). The prevalence of major depression was 13% and half of the patients suffered from severe depression according to MADRS. Depression affected more patients with low socioeconomic level (p = 0.037), suffering from a chronic medical condition (p = 0.0013), unmarried, divorced or widowed (p = 0.022). There were no statistically significance according to age, gender, living environment, alcohol abuse, and tobacco or life events. The frequency of suicidal thoughts or behavior was 3% in the sample and 19% among depressed patients.ConclusionNeed of further general practitioners training in systematic screening of depressive trouble is still requested.