The reduced form of nicotinamide adenine dinucleotide (NAD(P)H) behaves as an energy/chemical "currency", carrying hydrogen in a biologically convertible form and donates electrons in numerous biotransformations and artificial photosynthesis. Its high cost necessitates its regeneration for reuse where photocatalysis using light energy is attractive. However, high NAD(P)H yield is only achievable via organic mediators to transfer electrons.Here, we analyse the current issues in catalytic NAD(P)H regeneration and show that a continuous-flow reactor system can realise selective NAD(P)H regeneration with 100% yield using Pt/C3N4 as a photocatalyst.

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