sulted in a decrease in HBV recurrence and improved Liver transplantation for hepatitis B virus (HBV)-resurvival after transplantation. 5 However, despite the use of lated liver disease is complicated by HBV recurrence HBIG, patients with active HBV replication still experienced and, consequently, poor patient and graft survival. Paa high recurrence of HBV infection after liver transplantatients transplanted for hepatitis delta virus (HDV)-retion. lated cirrhosis are reported to have a diminished inciAn interesting subgroup of HBV-infected patients are those dence of HBV recurrence and improved graft survival.who are also infected with hepatitis delta virust (HDV). Such However, only a few reported HDV-infected patients had patients are reported to have a decrease in HBV recurrence active HBV replicative disease before liver transplantaand better survival after transplantation. The multicenter tion. In our experience, we transplanted two HDV-instudy in Europe reported 32% HBV recurrence and 85% surfected patients, both of whom had active HBV replicavival rate 3 years after transplantation in patients also intion before liver transplantation. In one patient, fected with HDV. 1 Recently, an HBV recurrence of only 13% hepatitis B surface antigen (HBsAg) recurred four and a 5-year actuarial survival rate of 88% was reported for months after transplantation. Two months later, Hepatiliver transplantation in patients with HDV infection. 6 All tis Be antigen (HBeAg) and HBV-DNA became positive, patients were also negative for HBV-DNA at the time of and the patient died of fulminant recurrent hepatitis B transplant. It has been suggested that suppressed HBV repliand hepatitis delta. In the other patient, HBV persisted cation in patients with HDV infection plays a role in the after transplantation, and 2 months later the patient rediminished recurrence of HBV. Indeed, the number of HDVquired retransplantation for fulminant recurrent hepainfected patients who had active replication of HBV before titis B and hepatitis delta. With the second graft, the transplantation was quite small. 6 patient remained free of HBV infection for 1 year. ThereThe outcome of patients with HDV infection who have acafter, the patient experienced HBV recurrence with active HBV replication remains undefined. Therefore, we report tive replication and died of fulminant hepatitis B and the clinical course of the only two HDV-infected patients who delta recurrence. In the first case and in the second graft underwent liver transplantation at our center. Both patients of the second case, hepatitis B immunoglobulin (HBIG) had active HBV replication before transplantation, noted by immunoprophylaxis was administered in an attempt to the presence of both hepatitis-Be-antigen (HBeAg) and HBVprevent recurrence of HBV. The literature suggests that DNA. Three liver transplantations were performed in these an HDV infection inhibits the replication of HBV and two patients, and both died because of fulminant recurrence therefore plays a role in preventing the rec...