A combined experimental and computational study of a turbulent multiple jet from lobed diffusers is performed. The main interest of these multiple lobed jets is to come up with the best configuration that improves the thermal and dynamic homogenization in air diffusion units that can be used for ventilation, heating and air conditioning of residential premises. Herein, the configuration of a central lobed jet surrounded by six equidistant peripheral lobed jets has been investigated. On the experimental level, flow velocities and temperatures were measured by a multifunctional thermo-anemometer. In terms of numerical simulation, the conservation equations of mass, momentum and energy are solved while involving four turbulence models, viz., the k-ϵ model, the k-ω, the shear stress transport (SST) k-ω model and the Reynolds Stress Model (RSM). The findings are compared with thermo-anemometer measurements. It turns out that the SST k-ω model is most appropriate for predicting the average flow characteristics.