The determination of high density lipoprotein (HDL)-cholesterol in patients with mild hypercholesterolemia (240-300 mg/dl) allows one to distinguish between hyperbetalipoproteinemia (= high atherogenic risk) and hyperalphalipoproteinemia (= low atherogenic risk). In addition, analysis of HDL-cholesterol is of value in the prediction and early recognition of coronary heart disease, particularly in combination with known risk factors (hypertriglyceridemia, adipositas, smoking). This prognostic value of HDL-cholesterol is a result of its negative correlation to coronary heart disease which has been recognized in epidemiologic and clinical studies. The study of Tangier disease (analphalipoproteinemia) and tissue culture experiments will provide opportunities for the further elucidation of the role of HDL in atherogenesis.

Twenty-eight elderly patients, mostly with minor electrocardiographic abnormalities, underwent cystometry and simultaneous recording of the electrocardiogram in order to assess the influence of intravesical pressure elevation with regard to electrocardiographic changes. During cystometry intra-atrial, atrioventricular and ventricular conducting time remained unaffected, while the cardiac rate showed a moderate but significant increase without any serious impairment of cardiac function. It is concluded that slow filling without overdistension of the bladder can be considered safe even in elderly patients with cardiovascular problems.

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