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SULPHUR INJECTIONS IN CHRONIC ARTHRITIS THE BRITISH1N with a general stimulation of metabolic processes-and. defence mechanisms. Holb6ll and Herborg4 showed that intramuscular injections of sulphur constantly produced a leucocytosis from 20,000 to 30,000 per c.mm., the increase being due almost entirely to polymorphonuclear cells, and Power5 demonstrated that in rabbits this was accompanied by a definite leucoblastic hyperplasia of' the bone marrow. Such a polymorphonuclear leucocytosis was a constant feature in our patients. If such leucoblastic reaction is accompanied by an increased mobilization of bactericidal or other antibodies as Gay and Claypole6 believe, we may have a partial explanation of the beneficial effect of treatment. More obvious, however, are certain vascular changes which may be observed in the affected joints following the injections, for pain, tenderness, stiffness, and swelling are all temporarily.increased, and the skin becomes hot, red,