In a prospective study of52 patients with ovarian malignancy followed up for 3-1 8 months the clinical significance of pre-operative serum CA 125 as ii tumour marker was assessed. In 41 patients with epithelial ovarian cancer. the level of CA 125 correlated wcll with tuniour load as indicated by F I G 0 stage. All epithelial histological types, including mucinous. released CA 125 although serouh and undifferentiated tuinours produced quantitatively more antigen. 'l'hcre was, however, no correlation between CA 125 concentration and histopathological grade. n o r did CA 125 level appear to be of any prognostic value in epithelial ovarian cancer. Elevated CA 125 levels were also found in patjcnts with sex cordistronial tumours, K r u k e n b e r g tumours. an ovarian sarcoma and a serous carcinoma of low malignant potential.

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