In order to study the effect of comprehensive rehabilitation intervention on the occurrence of ventilatorassociated pneumonia in critical patients, this study selected the critical patients admitted to Affiliated Hospital of Inner Mongolia Medical University as the research object, and performed routine rehabilitation treatment (control group) and comprehensive rehabilitation treatment (observation group), recorded and compared the success rate of ventilator weaning, incidence of ventilator-associated pneumonia, mechanical ventilation time, length of hospital stays in intensive care unit, clinical pulmonary infection score and acute physiology and chronic health evaluation II score. The result shows that the success rate of the observation group was significantly higher than that of the control group. The difference was statistically significant. The incidence of ventilator-associated pneumonia, mechanical ventilation time and hospitalization time in the intensive care unit were significantly lower in the observation group than in the control group. The difference was statistically significant. Compared with prior treatment, the clinical pulmonary infection score and acute physiology and chronic health evaluation II score of the two groups were significantly lower after treatment, and the difference was statistically significant. The clinical pulmonary infection score of the observation group after treatment was significantly lower than that of the control group and the difference was statistically significant, while the acute physiology and chronic health evaluation II score of the observation group after treatment was lower than that of the control group, but the difference was not statistically significant. Therefore, through the study of the impact of comprehensive rehabilitation intervention on the occurrence of ventilator-associated pneumonia in critical patients, comprehensive rehabilitation treatment for critical patients is safe and effective and can be used as a routine treatment in clinical intensive care unit. Although there are still some shortcomings in the research process, it still provides some basis and ideas for more precise research.