Depression is common but under-recognized in RA patients starting on anti-TNF therapy. Patients with persistent depression tended to respond less well to anti-TNF, with smaller reductions in DAS28. Given that a significant reduction in DAS28 is a requirement for continuing therapy, recognition and appropriate management of depression may improve TNF effectiveness.

In the title mol­ecule, C20H19NO3S, the dihedral angle between the phenyl rings is 48.93 (18)°, and they make dihedral angles of 38.37 (17) and 86.50 (19)° with the benzene ring. A weak intra­molecular C—H⋯O inter­action might stabilize the mol­ecular conformation. In the crystal, weak π–π stacking inter­actions between the benzene rings [centroid–centroid distance = 3.774 (2) Å] may help to establish the packing.

Abstract-In the present study, a series of N-substituted sulfonamides have been synthesized. The reaction of benzene sulfonyl chloride (1) with O-anisidine (2) yielded N-(2-methoxyphenyl) benzenesulfonamide (3), which on bromination with bromine in the presence of acetic acid gave N-(4,5-dibromo-2-methoxyphenyl)benzenesulfonamide (6). The two products (3) and (6)

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