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The whole body retention, excretion, lung clearance, distribution, and concentration of 191Pt in other tissues was determined in rats following a single inhalation exposure to different chemical forms of 191Pt. The chemical forms of 191Pt used in study were 191PtCl4, 191Pt(SO4)2, 191PtO, and 191Pt metal. Immediately after exposure most of the 191Pt was found in the gastrointestinal and respiratory tract. Movement of the 191Pt through the gastrointestinal tract was rapid, most of the 191Pt being eliminated within 24 hr after exposure. Lung clearance was much slower, with a clearance half-time of about 8 days. In addition to the lungs, kidney and bone contained the highest concentrations of 191Pt.

The whole body retention, excretion, lung clearance, distribution, and concentration of l9lPt in other tissues was determined in rats following a single inhalation exposure to different chemical forms of 19iPt. The chemical forms of 19iPt used in study were 191PtCI4, 191Pt(SO4)2, '9iPtO, and 19iPt metal. Immediately after exposure most of the 191Pt was found in the gastrointestinal and respiratory tract. Movement of the i9iPt through the gastrointestinal tract was rapid, most of the i9iPt being eliminated within 24 hr after exposure. Lung clearance was much slower, with a clearance half-time of about 8 days. In addition to the lungs, kidney and bone contained the highest concentrations of i9iPt.