Cloud computing is internet-distributed computing model transferring processes from personal computers or servers to cloud servers. Nowadays, security and performance of cloud computing is considered challenging for both users and cloud service providers. Securing data on cloud computing servers will ensures privacy, confidentiality, integrity, and availability. Using cryptographic techniques is one of the major methods to ensure the data security while storing and transmission. Hypervisor in a cloud is a software that provides abstraction and called virtual machine monitor. Hyper-V and Xen are two different types of hypervisors. In this paper, eight different types of cryptographic algorithms are deployed by using the two hypervisors with instances, to measure the hypervisors performance while encryption and decryption. CPU utilization and response time are measured while encryption and decryption are having different data types and sizes. Results show that Xen is better than Hyper-V in most results on average at 15% and 6.1% for time duration and CPU utilization respectively. Keywords: Cloud Computing, Virtualization, Hypervisors, Xen, Hyper-V, Cryptographic Algorithm