This research conducts the delineation process for a brain tumor on the radio therapy. Delineation means the imaging process of target volume that is conducted in the beginning of Treatment Planning System (TPS). Target volume consists of gross tumor volume (GTV), clinical target volume (CTV), planning target volume (PTV), and Organ at Risk (OAR). This research aims to delineate target volume and measure the target volume axial brain tumor. The images that are used are Magnetic Resonance Imaging (MRI) including axial, coronal, and sagittal slice. Evaluation is only done with one patient affected by a brain tumor. Delineation process is performed by the active contour segmentation method and volume calculations using Simpson integration method. The delineation of target volume is conducted by segmenting each slice of images moreover they are reconstructed until the three dimension of visualized target volume is obtained. Having done this process, target area and target volume calculations are conducted. This research results range error rate for target area is 0.0006 to 0.0059 and target volume is 0.0001 to 0.0013
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