We present a systematic literature review of cryptocurrency and blockchain research in Human-Computer Interaction (HCI) published between 2014 and 2021. We aim to provide an overview of the feld, consolidate existing knowledge, and chart paths for future research. Our analysis of 99 articles identifes six major themes: (1) the role of trust, (2) understanding motivation, risk, and perception of cryptocurrencies, (3) cryptocurrency wallets, (4) engaging users with blockchain, (5) using blockchain for application-specifc use cases, and (6) support tools for blockchain. We discuss the focus of the existing research body and juxtapose it to the changing landscape of emerging blockchain technologies to highlight future research avenues for HCI and interaction design. With this review, we identify key aspects where interaction design is critical for the adoption of blockchain systems. Doing so, we provide a starting point for new scholars and designers and help them position future contributions. CCS CONCEPTS• Applied computing → Digital cash; • Human-centered computing → Human computer interaction (HCI); Interaction design.