A psychophysical experiment has been carried out to investigate the impact of dynamic lighting parameters on atmosphere perception. The experiment was conducted in a purpose-built LED lighting lab, where the lighting could be spatially and dynamically changed and colorimetric specifications controlled. The aim of this study was to investigate the impacts of speed, saturation and brightness of dynamic lighting on the perceived atmosphere, preference and suitability for certain spaces. Twenty native Chinese observers participated in the experiment, each assessing the environment under dynamic lighting conditions using 21 atmosphere terms. The results show significant gender differences on some scales such as safe, spatial, chilly, formal, preference and office-like. Factor analysis showed that the 21 scales can be grouped into three categories: tenseness, coziness and liveliness, and that a living room-like atmosphere evaluation is consistent with coziness. Dynamic lighting does have a significant influence on atmosphere perception. A more saturated LED light would lead to less tense, more cosy, more safe and more lively atmosphere perceptions. By increasing the speed, a more tense and less cosy atmosphere can be generated. Medium speed offers the most lively and preferred atmosphere. Brighter lighting will generate a less tense environment. More saturated colour and a slower speed will produce a more living room-like environment, but it seems that such dynamic lighting is not suitable for an office-like environment.

The aim of this study was to evaluate the efficacy of recombinant adenovirus p53 agent (rAd-p53) injection combined with cisplatin (CDDP) for the treatment of malignant pleural or peritoneal effusion. After puncture drainage, patients in the treatment group (n = 27) received intracavitary administration of rAd-p53 (2 x 10(12) virus particles) once a week for 4 weeks. At 48 h after each rAd-p53 injection, patients were given intracavitary administration of cisplatin 60 mg/m(2). This administration procedure continued once a week for 4 weeks. The control group (n = 21) received the same intracavitary therapy as the treatment group but without rAd-p53 therapy. Efficacy was evaluated by clinical observations, computed tomography, tumour markers, Karnofsky score and short-term follow-up. The total effective rates for the treatment group (63.0%) were significantly higher than for the control group (42.9%), suggesting that the treatment group benefited over the control group. In conclusion, rAd-p53 therapy is a safe and effective treatment for advanced malignant pleural or peritoneal effusion.

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Purpose The authors sought to evaluate the efficacy of recombinant tissue plasminogen activator (r-TPA) in the treatment of severe fibrinous anterior chamber reactions secondary to endophthalmitis. Methods Twelve patients with endophthalmitis associated with severe fibrinous anterior chamber reactions were enrolled in the study. Various degrees of posterior synechiae were noted in 10 of these patients. TPA (25 lg/0.05 cc) was injected into the anterior chamber through the limbus as an adjunctive treatment to intravitreal antibiotic injection. Efficacy of the treatment was judged by the rate of fibrinolysis, the lysis of posterior synechiae, and the size of the dilated pupil. Results After application of 25 lg of r-TPA, the fibrin reaction gradually resolved in 2-14 h. The median dilated pupil size in ratio 24 h after r-TPA injection was significantly larger than before r-TPA injection (0.41 vs 0.60; P ¼ 0.002). The median difference in pupil size in ratio in patients with posterior synechiae larger than 1801 was significantly larger than those with posterior synechiae equal or less than 1801 (0.32 vs 0.09; P ¼ 0.003). At 24 h after application of r-TPA, no eye had posterior synechiae. Conclusion Intracameral injection of r-TPA may be a safe and effective method for the treatment of significant fibrin reaction in endophthalmitis and thus facilitates vitreous and fundus examinations and vitrectomy if necessary.

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.