Sepsis is caused by an aberrant regulatory host response toward an infection. It is linked to acute organ dysfunction and associated with high mortality. 1,2 Despite advances in care and treatment, sepsis remains the costliest disease to treat, with over $20 billion (5.2%) being spent annually in the United States. 3 The number of hospitalizations for sepsis cases in the United States even exceeds those for stroke and myocardial infarctions. 4 According to the statistics, 5 the incidence of sepsis is 500 per 100,000 cases and is on the rise. Globally, there are over 31 million sepsis cases; among them, 19.4 million cases are of severe sepsis associated with a mortality
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