No abstract

No abstract

Aims:To evaluate pulsatility index (PI) in patients with acute ischemic stroke (AIS) who underwent endovascular thrombectomy (EVT).Methods: Patients were retrospectively recruited if their stroke were secondary to middle cerebral artery (MCA) occlusion and achieved full recanalization after EVT.Transcranial Doppler was performed within 24-hour post-EVT. The primary outcome was correlation between the MCA-PI on the affected side and 3-month functional outcome, with modified Rankin scale (mRS) ≥5 indicated extremely poor functional outcomes.Results: Totally, 170 patients were included. High MCA-PI was positively related to the 3-month mRS score (r = 0.288, p < 0.001). The highest quartile of the MCA-PI was associated with a high incidence of extremely poor functional outcomes (adjusted OR, 13.33; 95% CI, 2.65-67.17; adjusted p = 0.002) after adjusting for confounding factors. The predictive capacity of the MCA-PI for extremely poor functional outcomes was good (area under the curve, 0.755; 95% CI, 0.655-0.854; p < 0.001), and its cutoff value for predicting extremely poor outcomes was 1.04, with a sensitivity of 65.6% and specificity of 78.3%. Conclusion:The MCA-PI on the affected side is a prognostic biomarker in patients who have undergone stroke thrombectomy. An elevated MCA-PI may be prognostically valuable for predicting extremely poor functional outcomes.

Ischemic stroke is one of the major disabling health‐care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a potential therapeutic strategy on stroke rehabilitation by evaluating the existing evidence and puts forward some remaining questions to clarify and future researches to be performed in the field.