The 3 0 -flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching Graphical abstract Highlights d XPF-ERCC1 deficiency impairs alternative end joining (A-EJ)mediated class switching d 3 0 flap endonuclease, but not NER function of XPF-ERCC1, is required for A-EJ d Loss of ERCC1 impedes joining of resected 3 0 flap DSB ends d ERCC1 enhances c-myc-IgH translocation in Lig4-deficient cells

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