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Background and Objectives: Acute Kidney Injury (AKI) due to bilateral ureteral obstruction in older patients typically raises concerns of abdominal, retroperitoneal, or pelvic neoplasms. Aim of the present paper is to analyse the acute kidney injury after ureteral obstruction due to signet ring cell adenocarcinoma of the bladder. Materials and Methods: This descriptive clinical study was conducted in Lahore General Hospital, Lahore during January 2019 to November 2019. The data was collected from 10 patients of age range 40 to 60 years. This data include mainly male patients. These selected patients started with hematuria complaint, associated with left flank pain of intensity 8/10 and abrupt onset during his work. Results: The data was collected from 10 patients of AKI after Ureteral Obstruction Due to Signet Ring Cell Adenocarcinoma of the Bladder. The mean age of the patients was 56.56±8.46 years. The BMI of the selected patients was 24.31±2.26 kg/m2 and all basic values are presented in table 01. Conclusion: It is concluded that adenocarcinoma is a rare type of bladder cancer, with the subtype signet ring cell adenocarcinoma even rarer.