The work demonstrates the effect of cold atmospheric plasma (CAP) on adult female rats suffering from osteoporosis, the used plasma was generated by a floating electrode-dielectric barrier discharge system with an electrode diameter of 3 cm. The output power was from (12-20) watts. The effect of non-thermal plasma was observed on rats with various exposure times of 20, 30, and 40 sec. It was noted that the blood calcium percentage of animals exposed to cold plasma increased, as well as an increase in the level of vitamin D3 at the same time, it is noted that there is no effect on parathyroid hormone level. For the thyroid gland, it is noticed an increase in the level of T3, and T4 hormones in the blood during the period of induction for osteoporosis, and when exposed to cold plasma, a decrement was noticed in the level of the two hormones reached the normal level at the same time. There was no effect on thyroid-stimulating hormone and for periods of exposure in the female plasma, these results give an indication that cold plasma can be used to treat or reduce osteoporosis. Finally, the histopathology and energy dispersive x-ray anyalysis (EDX) analysis processes were done, This gives a positive indication for the use of cold plasma in the treatment of many bone-related diseases.

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