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SUMMARYPersonal e-healthcare service is growing significantly. A large number of personal e-health measuring and monitoring devices are now in the market. However, to achieve better health outcome, various devices or services need to work together. This coordination among services remains challenge, due to their variations and complexities. To address this issue, we have proposed an ontology-based framework for interactive selfassessment of RESTful e-health services. Unlike existing e-health service frameworks where they had tightly coupling between services, as well as their data schemas were difficult to change and extend in the future. In our work, the loosely coupling among services and flexibility of each service are achieved through the design and implementation based on HYDRA vocabulary and REST principles. We have implemented clinical knowledge through the combination of OWL-DL and SPARQL rules. All of these services evolve independently; their interfaces are based on REST principles, especially HATEOAS constraints. We have demonstrated how to apply our framework for interactive self-assessment in e-health applications. We have shown that it allows the medical knowledge to drive the system workflow according to the event-driven principles. New data schema can be maintained during run-time. This is the essential feature to support arriving of IoT (Internet of Things) based medical devices, which have their own data schema and evolve overtime. key words: ontology-based knowledge model, ontology-based health information, ontology-based application programming interface, RESTful service composition, HATEOAS