Melting points were determined on an Electrothermal capillary fine control apparatus and are uncorrected. IR spectra were obtained on a Shimadzu FT IR 8201 PC spectrophotometer and only significant absorption band frequencies are cited. 1 H and 13 C NMR spectra were recorded on a Bruker DPX-250 AVANCE at 250.13 and 62.9 MHz respectively in DMSO-d6. Chemical shifts (δ) are given in part per million downfield from TMS as an internal standard and J values in Hz.Elemental analyzes (C, H, N, S) were used to confirm the purity of all compounds and were performed on a CHN Muriel ESCADEILLAS apparatus. The chemicals were used as obtained commercially.
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Solvent-Free Synthesis of Dihydropyridines and Acridinediones via a Salicylic Acid-Catalyzed Hantzsch Multicomponent Reaction. -Salicylic acid is found to be an extremely useful and highly efficient catalyst for the synthesis of the title compounds (III) and (VI) by three-component condensation of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate. -(KHODJA, I. A.; GHALEM, W.; DEHIMAT, Z. I.; BOULCINA, R.; CARBONI, B.; DEBACHE*, A.; Synth. Commun. 44 (2014) 7, 959-967, http://dx.
A facile and efficient synthesis of new 1,4‐dihydropyridine derivatives was reported via Hantzsch three‐component condensation reaction of aldehydes or formylphenylboronic acids, ethyl acetoacetate, and ammonium acetate in the presence of a catalytic amount of triethylamine under solvent‐free conditions. The method described here offers several advantages including high yields, short reaction times, and simple work‐up procedure.
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