In order to analyze the primary sources of air pollutants in Chang-Zhu-Tan region, this article selected the environmental monitoring data and meteorological data in the winter of 2019 to calculate the backward airflow trajectories with the Chang-Zhu-Tan region as the starting point by using the backward trajectory model. Combined with the ground concentration monitoring data, cluster analysis, potential source contribution factor (PSCF) analysis, and concentration weighted trajectory (CWT) analysis were carried out to determine the pollutant transportation paths and sources of the potential source area. The results show that air mass transportation mainly comes from three directions: northwest, northeast, and southwest China. The airflow in northwest China moves faster and cleaner, while the airflow from the northeast and southwest moves slowly and carries a high concentration of pollutants. PSCF and CWT analyses show that the critical potential sources are mainly located in this area and some cities next to the study area. This study has important practical significance for the environmental research of Chang-Zhu-Tan region and can provide theoretical reference for regional joint prevention and control of air pollution.